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03 Jun 2024

Improved wound healing by PLASOMA: 62% of complex wounds heals versus 25% with Standard of care


Publication on RCT with PLASOMA cold plasma – in Advances in Wound Care, online on 3 June 2024. Authors: Olaf Bakker, Paulien Smits, Chantal van Weersch, Melissa Quaaden, Esther Bruls, Angela van Loon and Joost van der Kleij

PLASOMA treatment once or twice a week could substantially improve wound healing of venous leg ulcers (VLUs) in primary care.

Methods:

In this randomized controlled trial (RCT), 46 patients with VLU were divided over three groups: the control group received standard wound care, the two treatment groups received standard wound care plus once or twice a week PLASOMA treatment. All treatments were performed by wound nurses, wound consultants, and nursing specialists, either at outpatient wound care centers or at the patients’ residences. Primary aim: evaluate the number of wounds that has healed within 12 weeks.

Results: The RCT showed a high efficacy in wound healing and wound area reduction.

Bar chart showing percentage of wounds healed within 12 weeks: 25% control, 53% with weekly treatment, and 62% with twice-weekly treatment.

“Bar chart showing percentage reduction in wound surface area within 12 weeks: 53% control, 64% with weekly treatment, and 95% with twice-weekly treatment

Within 12 weeks, 53% of wounds healed in the group that received one PLASOMA treatment per week and 62% in the group that received two PLASOMA treatments per week, compared to only 25% in the control group.

The average reduction in wound surface area was 64% in the group with one PLASOMA treatment per week and 95% in the group with two PLASOMA treatments per week, compared to 53% in the control group.

Conclusion

Together with other clinical safety and efficacy data, these results support the integration of PLASOMA as a valuable therapy for complex wounds.

Source: Improved Wound Healing by Direct Cold Atmospheric Plasma Once or Twice a Week: A Randomized Controlled Trial on Chronic Venous Leg Ulcers

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